The storage of lipids in white adipose tissue (WAT) is a conserved trait that functions to both insulate from the cold, and to store energy to defend against bouts of famine. Researchers have identified 100s of genes that are important in this process, which impact pathways including adipocyte endocrine function, differentiation and energy homeostasis. It is clear that factors such as lifestyle, biological sex, and ageing can influence these processes, and that their dysregulation promotes obesity and disease. Given that obesity remains a major global health issue, it is important that we continue investigating these pathways to better manage this condition, and develop new therapeutics. This talk will present data demonstrating that the gene Trim28 is an important mediator of sex specific differences in adiposity.